Thermo Fisher Scientific PDGFRA Monoclonal Antibody (16A1), PE

Applications

Flow Cytometry (Flow)

• Tested Dilution: 20 µL / 1×10⁶ cells
• Publications: View 1 publication

Miscellaneous PubMed (Misc)

• Publications: View 1 publication

Product Specifications

Additional Formats

• Unconjugated
• APC
• Biotin
• FITC
• Request custom conjugation

Product Specific Information

This antibody recognizes an extracellular epitope of CD140a / PDGF-RA, the 170 kDa alpha chain of platelet-derived growth factor receptor, which is widely expressed on a variety of mesenchymal-derived cells and plays pro-proliferative or anti-proliferative roles in various tumors.

Target Information

PDGFRA is a cell surface receptor tyrosine kinase that binds members of the platelet-derived growth factor family. These growth factors act as mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or heterodimer composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Knockout mouse studies indicate that PDGFRA is crucial for kidney development, as heterozygous mice exhibit defective kidney phenotypes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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