Thermo Fisher Scientific alpha Actinin 4/ACTN4 Polyclonal Antibody
Rabbit polyclonal antibody targeting human alpha Actinin 4 (ACTN4). Validated for WB and IP applications. Recognizes residues 1–50 region. Supplied as 1 mg/mL liquid, stored at 4°C. Predicted cross-reactivity with Rat and Bovine.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 1 to 50 of human Alpha-actinin-4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Rat and Bovine
Target Information
Alpha actinins belong to the spectrin gene superfamily, representing a diverse group of cytoskeletal proteins, including alpha and beta spectrins and dystrophins.
Alpha actinin is an actin-binding protein with multiple roles in different cell types.
In nonmuscle cells, it is found along microfilament bundles and adherens-type junctions, where it binds actin to the membrane.
In muscle cells, isoforms are localized to the Z-disc or analogous dense bodies, anchoring myofibrillar actin filaments.
This gene encodes a nonmuscle alpha actinin isoform concentrated in the cytoplasm and thought to be involved in metastatic processes.
Mutations in this gene have been associated with focal and segmental glomerulosclerosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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