Thermo Fisher Scientific MMP2 Monoclonal Antibody (OTI4B11), TrueMAB
MMP2 단백질을 인식하는 Mouse Monoclonal Antibody로 Western Blot에 최적화됨. Human 시료에 반응하며, TrueMAB 기술로 제작됨. PBS, BSA, 글리세롤 기반 완충액에 보관되며 -20°C에서 안정적. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:2,000 | Miscellaneous PubMed (Misc) – View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4B11 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 228–507 of human MMP2 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Matrix metalloproteinases (MMPs) are proteolytic enzymes capable of degrading components of connective tissue. They share a conserved activation mechanism and a metal-binding active site region, and are regulated by tissue inhibitors of metalloproteinases (TIMPs). MMPs and TIMPs play key roles in angiogenesis regulation.
MMP2 is synthesized as a 631 amino acid proenzyme, activated by cleavage of the first 80 amino acids, and contains propeptide, catalytic, and hemopexin domains. The MMP family includes at least eighteen secreted and membrane-bound zinc endopeptidases that collectively degrade extracellular matrix components such as collagens, fibronectin, laminin, and basement membrane glycoproteins.
Functionally, MMP2 is involved in tissue remodeling. Mutations in the MMP2 gene are associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms of MMP2 have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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