Thermo Fisher Scientific MMP2 Monoclonal Antibody (OTI4B11), TrueMAB

Applications and Tested Dilution

Product Specifications

Target Information

Matrix metalloproteinases (MMPs) are proteolytic enzymes capable of degrading components of connective tissue. They share a conserved activation mechanism and a metal-binding active site region, and are regulated by tissue inhibitors of metalloproteinases (TIMPs). MMPs and TIMPs play key roles in angiogenesis regulation.

MMP2 is synthesized as a 631 amino acid proenzyme, activated by cleavage of the first 80 amino acids, and contains propeptide, catalytic, and hemopexin domains. The MMP family includes at least eighteen secreted and membrane-bound zinc endopeptidases that collectively degrade extracellular matrix components such as collagens, fibronectin, laminin, and basement membrane glycoproteins.

Functionally, MMP2 is involved in tissue remodeling. Mutations in the MMP2 gene are associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms of MMP2 have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.