Thermo Fisher Scientific TYMS Monoclonal Antibody (OTI1B1), TrueMAB

Applications and Tested Dilutions

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

Thymidylate Synthase (TS) catalyzes the conversion of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), a key step in DNA biosynthesis.
TS is a major target of fluoropyrimidine-based antineoplastic drugs used for treating solid tumors. In tumor cells, 5-FU and fluorodeoxyuridine are converted to FdUMP, which inactivates TS by forming a ternary complex with the folate cofactor 5,10-methylenetetrahydrofolate.
Expression of TS correlates with response to 5-fluorouracil (5-FU) in colorectal, gastric, head and neck, and breast carcinomas.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.