Thermo Fisher Scientific ZBP1 Polyclonal Antibody
인간 ZBP1에 특이적인 폴리클로날 항체로 면역조직화학(IHC) 등 다양한 연구용으로 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, 액상 형태로 제공. 단기 4°C, 장기 -20°C 보관 권장. 비진단 연구용 전용 제품.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human ZBP1. Recombinant protein control fragment (Product #RP-99403). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2649753 |
Product Specific Information
Immunogen sequence:
GHGNIITRQT VSREDGSAGP RHLPSMAPGD SSTWGTLVDP WGPQDIHMER SILRRVQLGH SNEMRLHGVP SEGPAHIPPG SPPVSATAAG PEASFEARIP SPG
Antigen sequence identity:
- Mouse: 40%
- Rat: 44%
Target Information
Z-DNA binding protein 1 (ZBP1) belongs to a family of proteins containing the Zalpha domain, which binds specifically to left-handed Z-DNA and Z-RNA.
ZBP1 was initially identified as a gene up-regulated in activated macrophages of mice bearing ascites tumors, suggesting a role in host response and neoplasia.
Recent studies indicate that cytosolic ZBP1 can act like the toll-like receptor TLR9 by detecting cytosolic double-stranded DNA and triggering induction of type I interferon and other innate immune responses.
Binding of ZBP1 to dsDNA enhances its association with innate immune response proteins such as IRF3 and TBK1.
Multiple isoforms of ZBP1 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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