Thermo Fisher Scientific Chlormadinone Acetate Polyclonal Antibody

Applications

Tested Dilution

Publications

ELISA (ELISA)

5-10 µg/mL

-

Product Specifications

Species Reactivity

Chemical

Host/Isotype

Sheep / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Chlormadinone acetate(3)-BTG

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Purification

purified

Storage buffer

PBS, pH 7.4

Contains

0.09% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_1089879

Product Specific Information

Working Concentration: 1.25 µg/mL. Sensitivity: 10 ng/mL Chlormadinone Acetate produces 94% inhibition in a competitive ELISA employing Chlormadinone Acetate polyclonal antibody.

Target Information

Chlormadinone Acetate is the actetate salt form of chlormadinone, a synthetic progestin with antiandrogenic and antigonadotropic effects. Chlormadinone acetate (CMA) is a potent progesterone receptor (PR) agonist, a partial androgen receptor (AR) antagonist and a weak glucocorticoid receptor (GR) antagonist. Chlormadinone binds to PRs, which induces the expression of progesterone-responsive genes. In addition, chlormadinone blocks ARs in target organs and reduces the activity of skin 5 alpha-reductase; thus inhibiting androgen production and signaling. Through the negative feedback action on the hypothalamus-pituitary system, chlormadinone also suppresses gonadotropin secretion, which prevents ovarian and adrenal androgen production. Therefore, this agent decreases endometrial thickness, increases the viscosity of cervical mucus, inhibits ovulation and suppresses follicular growth and maturation. [National Center for Biotechnology Information. PubChem Compound Database; CID=9324].

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.