Thermo Fisher Scientific SH3BP4 Monoclonal Antibody (2B6)
SH3BP4 단백질을 인식하는 Mouse monoclonal antibody(2B6)로, Western blot과 ELISA에 적합합니다. Human 시료에 반응하며, Affinity chromatography로 정제되었습니다. PBS(pH 7.4) 용액 형태로 제공되며, -20°C에서 보관합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| ELISA | 1 ng/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2B6 |
| Immunogen | SH3BP4 (AAH57396, 1 a.a. ~110 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 kDa. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
MAAQRIRAAN SNGLPRCKSE GTLIDLSEGF SETSFNDIKV PSPSALLVDN PTPFGNAKEV IAIKDYCPTN FTTLKFSKGD HLYVLDTSGG EWWYAHNTTE MGYIPSSYVQ
Target Information
SH3BP4 was initially isolated as a novel cDNA using differential display analysis from cultured human corneal fibroblasts.
The protein contains three Asn-Pro-Phe (NPF) motifs, an SH3 domain, a PXXP motif, a bipartite nuclear targeting signal, and a tyrosine phosphorylation site.
SH3BP4 interacts with endocytic proteins such as clathrin, dynamin, and the transferrin receptor (TfR), localizing to TfR-containing coated pits and vesicles.
It is involved in cargo-specific control of clathrin-mediated endocytosis, particularly regulating TfR internalization.
At least two isoforms of SH3BP4 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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