Thermo Fisher Scientific FGR Polyclonal Antibody

Applications

• Western Blot (WB): Tested dilution 1:500–1:3,000

Product Specifications

Product Specific Information

• Recommended positive controls: 293T, A431, H1299, HeLa, HepG2, Molt-4, Raji
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

FGR is a SRC-related kinase present in hematopoietic cells. It signals within multiple pathways, including the integrin pathway and downstream of chemokine and cytokine receptors. The protein contains N-terminal sites for myristylation and palmitoylation, a PTK domain, and SH2 and SH3 domains that mediate protein-protein interactions with phosphotyrosine-containing and proline-rich motifs. It localizes to plasma membrane ruffles and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in overexpression of this protein.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information: www.P65Warnings.ca.gov

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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