Thermo Fisher Scientific MHC class 1 antigen B 15 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

Assay-dependent

-

Immunohistochemistry (Paraffin) (IHC (P))

Assay-dependent

-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500

-

Immunocytochemistry (ICC/IF)

1:100-1:500

-

ELISA (ELISA)

1:500-1:1,000

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human MHC class I antigen B 15, amino acids 65-130. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:HLA-B15,uniProtId:P01889-1,ncbiNodeId:9606,antigenRange:65-130,antigenLength:362,antigenImageFileName:BS-4120R_HLA-B15_P01889-1_Rabbit.svg,antigenImageFileNamePDP:BS-4120R_HLA-B15_P01889-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

HLA-B15 (B15) is an HLA-B serotype. The serotype identifies the B15 gene-allele protein products of HLA-B. B15 is a broad antigen can be subdivided into several split antigens that are often used in characterization. These are B62, B63, B70, B71, B72, B75, B76, B77. B15 is the largest allele grouping for any known human autosomal locus, identified as of August 2008 there are more than 150 alleles and approximately 140 amino acid sequence variants from those gene products. Some of these alleles are discussed below. HLA-B15 allele 1502 is associated with the severe skin conditions Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) caused by carbamazepine drug sensitivity in East Asians.

HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.