Thermo Fisher Scientific BIN1 Polyclonal Antibody

Thermo Fisher Scientific BIN1 Polyclonal Antibody

Applications

• Western Blot (WB)

Tested Dilution

• 1.0 µg/mL

Product Specifications

Product Specific Information

This target displays homology in the following species:

• Cow: 100%
• Dog: 100%
• Horse: 100%
• Human: 100%
• Mouse: 100%
• Pig: 100%
• Rabbit: 100%
• Rat: 100%
• Zebrafish: 100%

Target Information

This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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