Thermo Fisher Scientific IKBIP Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

Immunogen sequence:
IHSVLRVSQDL IETEKKMEDL TMQMFNMEDD MLKAVSEIME MQKTLEGIQY DNSILKMQNE LDILKEKVHD FIAYSSTGE

Highest antigen sequence identity to the following orthologs: mouse 86%, rat 85%.

Target Information

IKIP (Inhibitor of nuclear factor kappa-B kinase-interacting protein, IKK-interacting protein) is a single-pass membrane protein that shares a common promoter with APAF1. APAF1 and IKIP are both induced by X irradiation, however, the two gene products are transcribed in different directions. The IKIP gene is believed to be a target for p53 as expression of IKIP has been shown to promote apoptosis. IKIP has four known isoforms, three of which are found traversing the endoplasmic reticulum membrane. IKIP isoform 4 has a deletion of the transmembrane region which leads to a homogenous distribution of the protein within the cell. The IKIP gene products are expressed in vascular endothelial cells, while the isoform 4 has also been detected in lung, kidney, spleen, thymus, and skeletal muscle.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.