Thermo Fisher Scientific ASAH3 Polyclonal Antibody
인간 ASAH3 유래 합성 펩타이드로 제작된 Rabbit Polyclonal 항체. Western blot에 사용 가능하며 1:1,000 희석 비율로 검증됨. 액상 형태로 제공되며 -20°C에서 보관. 연구용으로만 사용 가능.
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Applications
- Western Blot (WB): Tested dilution 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human ASAH3 (UniProt ID: Q8TDN7-1, antigen range: 149–176, antigen length: 264) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2691556 |
Target Information
Ceramides are synthesized during epidermal differentiation and accumulate within the interstices of the stratum corneum, where they represent critical components of the epidermal permeability barrier. Excess cellular ceramide can trigger antimitogenic signals and induce apoptosis, and the ceramide metabolites sphingosine and sphingosine-1-phosphate (S1P) are important bioregulatory molecules.
Ceramide hydrolysis in the nucleated cell layers regulates keratinocyte proliferation and apoptosis in response to external stress. Ceramide hydrolysis also occurs at the stratum corneum, releasing free sphingoid base that functions as an endogenous antimicrobial agent.
ACER1 is highly expressed in epidermis and catalyzes the hydrolysis of very long chain ceramides to generate sphingosine.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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