Thermo Fisher Scientific FNTB Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1.0 µg/mL

Product Specifications

Product Specific Information

This target displays homology in the following species:
Cow: 100%; Dog: 100%; Guinea Pig: 86%; Horse: 93%; Human: 100%; Mouse: 93%; Rabbit: 93%; Rat: 100%

Target Information

Eukaryotic cells contain three different types of prenyltransferases that attach either a farnesyl group (15 carbons) or a geranylgeranyl group (20 carbons) in thioether linkage to C-terminal cysteine residues in various proteins. These posttranslational modifications enable membrane localization of proteins lacking transmembrane domains.

CAAX farnesyltransferase (FTase) attaches a farnesyl group from farnesyl pyrophosphate to cysteine residues at the fourth position from the C terminus of proteins ending in the CAAX box, where C is cysteine, A is typically an aliphatic amino acid, and X is usually methionine or serine. The enzyme can farnesylate peptides as short as four residues that conform to the CAAX consensus sequence.

The gene for the beta subunit of CAAX farnesyltransferase (FNTB) has been localized to 14q23-q24 by Southern blot hybridization and PCR analyses of human/Chinese hamster somatic cell hybrid lines and by fluorescence chromosomal in situ hybridization.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.