Thermo Fisher Scientific Progesterone Receptor (Marker of Progestin Dependence) Monoclonal Antibody (PR484)
인간 프로게스테론 수용체(PGR)를 표적하는 PR484 단클론 항체로, IHC(P) 및 IHC(PFA) 분석에 사용 가능. 단백질 A/G로 정제된 액상 형태이며, 보존제 무첨가. 연구용으로만 사용되며 생식 관련 프로게스테론 의존성 연구에 적합.
- 카탈로그번호
- 5241-MSM1-P1ABX
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Progesterone Receptor (Marker of Progestin Dependence) Monoclonal Antibody (PR484)
Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: Assay-dependent
Immunohistochemistry (PFA fixed) (IHC (PFA))
- Tested Dilution: 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | PR484 |
| Immunogen | Recombinant full-length human Progesterone Receptor protein (PGR) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The progesterone receptor (PR) is a member of the steroid family of nuclear receptors. It mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy.
PR exists as a 94 kDa protein (Form A) and a 120 kDa protein (Form B) due to alternative translation initiation sites.
- PR-B: Transcriptionally active form; activates genes for endometrium maintenance, pregnancy, and inhibition of ovulation.
- PR-A: Identical to PR-B except for a 165 amino acid deletion at the N-terminus, exposing a 140 amino acid inhibitory domain (ID) that represses steroid hormone transcriptional activity.
In its inactive state, PgR forms a multiprotein complex with heat shock proteins and immunophilins. Upon progesterone binding, the receptor undergoes conformational changes enabling dimerization and binding to progesterone response elements (PRE), activating transcription.
A null mutation in the PGR gene leads to pleiotropic reproductive abnormalities.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.