Thermo Fisher Scientific Anthrax Protective Antigen Synthetic Peptide
Anthrax 보호 항원 중간 영역의 16개 아미노산 서열로 구성된 합성 펩타이드입니다. Bacillus anthracis 관련 연구용으로 사용되며, 비결합형 액상 형태입니다. PBS 버퍼(pH 7.2, 0.1% BSA)에서 정제되어 −20°C에 보관합니다.
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Thermo Fisher Scientific Anthrax Protective Antigen Synthetic Peptide
Applications
- Control (Ctrl): Assay-dependent
- Blocking Assay (BLOCK): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bacteria |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C |
Product Specific Information
This peptide corresponds to 16 amino acids near the middle of Anthrax protective antigen.
Target Information
Anthrax infection is initiated by the inhalation, ingestion, or cutaneous contact with Bacillus anthracis endospores. B. anthracis produces three polypeptides that comprise the anthrax toxin: protective antigen (PA), lethal factor (LF), and edema factor (EF).
PA binds to two related proteins on the cell surface—tumor epithelial marker 8 (TEM8)/anthrax toxin receptor (ATR) and capillary morphogenesis protein 2 (CMG2)—though the physiologically relevant receptor remains unclear.
After PA binds to its receptor, it is cleaved by a furin-like protease into two fragments. The bound fragment associates with LF and EF, forming a complex that is endocytosed, enabling LF and EF translocation into the cytoplasm. These toxins typically induce rapid cell death and can be fatal to the organism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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