Thermo Fisher Scientific mPR gamma Polyclonal Antibody

Applications

Immunocytochemistry (ICC/IF)

• Tested Dilution: 0.25–2 µg/mL

Product Specifications

Product Specific Information

• Immunogen sequence: RLFLFPGESAQ NEATSYHQK
• Highest antigen sequence identity to the following orthologs: mouse 80%, rat 80%

Target Information

The steroid progesterone induces the resumption of maturation in oocytes via a nongenomic pathway through binding to a novel membrane progestin receptor (mPR). This pathway inhibits adenylyl cyclase, reduces intracellular cAMP, and activates mitogen-activated protein kinase to effect signal transduction pathways.
Three distinct groups, designated alpha, beta, and gamma, comprise this gene family. While all contain 7 transmembrane domains, they show distinct distributions in reproductive, neural, kidney, and intestinal tissues. These characteristics separate them from nuclear progestin receptors and imply similarity to G-protein coupled receptors.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.