Thermo Fisher Scientific BCLAF1 Polyclonal Antibody
BCLAF1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체입니다. Western blot과 IHC(Paraffin)에 적합하며, Human 시료에 반응합니다. 고순도 Protein A 및 항원 친화 크로마토그래피로 정제되어 높은 특이성과 재현성을 제공합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 658–687 amino acids from the C-terminal region of human BCLAF1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2541968 |
Target Information
BCLAF1 is an intracellular, death-promoting transcriptional repressor of survival genes that interacts with several members of the BCL2 family of proteins. It shows homology to the basic leucine zipper (bZIP) and MYB DNA-binding domains.
In apoptotic cells, BCLAF1 localizes to dot-like structures throughout the nucleus and redistributes near the nuclear envelope. Overexpression induces apoptosis, which can be suppressed by co-expression of BCL2 proteins. Also known as BTF, it triggers a proapoptotic signal that may help overcome resistance to STI571. BCLAF1 is predominantly expressed in skeletal muscles.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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