Thermo Fisher Scientific MAPKBP1 Polyclonal Antibody
MAPKBP1 단백질을 인식하는 토끼 다클론 항체로, Western blot에 적합합니다. 인간 유래 항원으로 제작되었으며, PBS 버퍼에 보존됩니다. 고순도의 Affinity chromatography 정제 제품으로, -20°C에서 보관합니다.
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Applications
- Western Blot (WB): 0.2–1.0 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the N-terminal region of human MAPKBP1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2688945 |
Product Specific Information
This target displays homology in the following species:
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%
Target Information
MAP kinases play a significant role in many biological processes, including cell adhesion and spreading, cell differentiation, and apoptosis.
MAPKBP-1 (mitogen-activated protein kinase binding protein 1), also known as JNKBP-1, is a 1,514 amino acid protein that contains twelve WD repeats. Induced by TRAF2 (TNF receptor-associated factor 2) and Tak1 (TGF-beta-activated kinase 1), MAPKBP-1 acts as an adaptor protein for NF-kappaB activation. It interacts with JNK3 and may promote TRAF2 polyubiquitination.
MAPKBP-1 exists as six alternatively spliced variants and is encoded by a gene located on human chromosome 15. Human chromosome 15 houses over 700 genes and comprises nearly 3% of the human genome. Several genetic disorders such as Angelman syndrome, Prader-Willi syndrome, Tay-Sachs disease, and Marfan syndrome are associated with defects in chromosome 15-localized genes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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