Thermo Fisher Scientific ASCL1 Polyclonal Antibody
ASCL1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 IHC에 적합합니다. 인간 시료에 반응하며 Protein A로 정제되었습니다. PBS(2% sucrose) 버퍼에 0.09% sodium azide가 포함되어 있습니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 - 1.25 µg/mL |
| Immunohistochemistry (IHC) | 5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the N-terminal of human ASCL1 (aa 48–97) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2608630 |
Product Specific Information
Peptide sequence:
QSAQQQQQQQ QQQQQAPQLR PAADGQPSGG GHKSAPKQVK RQRSSSPELM
Sequence homology:
Cow: 100%
Dog: 92%
Guinea Pig: 100%
Human: 100%
Mouse: 92%
Rabbit: 92%
Rat: 92%
Target Information
ASCL1 (also known as ASH1) is a basic helix-loop-helix transcription factor required for early nervous system development. It is expressed in the fetal brain and is essential for the development and survival of subsets of autonomic neurons. ASCL1 interacts with MEF-2A to regulate gene expression critical for neuronal circuit formation in the central nervous system.
High ASCL1 expression is observed in neuroendocrine tumors such as medullary thyroid cancer, small cell lung cancer, and other lung cancers with neuroendocrine features, making it a useful marker for such cancers.
The ASCL1 gene maps to human chromosome 12 and contains a trinucleotide repeat region, which may be associated with inherited diseases.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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