Thermo Fisher Scientific CTDSP1 Monoclonal Antibody (OTI1G1), TrueMAB
CTDSP1 단백질을 인식하는 Mouse monoclonal antibody로 Western blot 및 IHC(P)에서 검증됨. Human 시료에 반응하며, Affinity chromatography로 정제된 액상 형태. PBS 기반 buffer에 1% BSA, 50% glycerol 포함. -20°C에서 보관 권장.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1G1 |
| Immunogen | Full length human recombinant protein of human CTDSP1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.84 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
CTDSP1 is a class 2C phosphatase with activity dependent on the conserved DxD motif. Expression of CTDSP1 inhibits activated transcription from several promoter-reporter gene constructs, while a mutant lacking phosphatase activity enhances transcription.
Neuronal gene transcription is repressed in nonneuronal cells by the REST/NRSF complex, which recruits SCPs to neuronal genes containing RE1 elements, leading to neuronal gene silencing. Phosphatase-inactive forms of SCP interfere with REST/NRSF function and promote neuronal differentiation of P19 stem cells. Similarly, RNA interference targeting Drosophila SCP unmasks neuronal gene expression in S2 cells. Thus, SCP activity is an evolutionarily conserved transcriptional regulator that globally silences neuronal genes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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