Thermo Fisher Scientific IDH2 Monoclonal Antibody (GT673)
IDH2 단백질을 인식하는 Mouse IgG1 단일클론 항체로, WB, IHC, ICC/IF에 사용 가능. 인간, 생쥐, 랫드 반응성. Protein G 정제, PBS 용액 형태로 제공. 에너지 대사 관련 IDH2 연구에 적합.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | GT673 |
| Immunogen | Recombinant fragment corresponding to amino acids 56–345 of IDH2 (Uniprot ID#P48735) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term; for long-term storage, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2538737 |
Product Specific Information
- Recommended positive controls: HepG2, Jurkat, Raji, K562, THP-1, NCI-H929, mouse brain, rat brain, DDDDK-tagged IDH2-transfected 293T
- Predicted reactivity: Mouse (97%), Rat (96%), Zebrafish (89%), Xenopus laevis (91%), Pig (96%), Chicken (95%), Rhesus Monkey (100%), Bovine (96%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses: one utilizing NAD and the other NADP as electron acceptors. Five isocitrate dehydrogenases have been reported—three NAD-dependent (mitochondrial matrix) and two NADP-dependent (one mitochondrial, one cytosolic). The NADP-dependent mitochondrial isozyme encoded by this gene plays a role in intermediary metabolism and energy production, and may associate with the pyruvate dehydrogenase complex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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