Thermo Fisher Scientific CaMKII alpha Polyclonal Antibody
Rabbit polyclonal antibody against CaMKII alpha for WB, IHC, ELISA, and IP applications. Recognizes recombinant human CaMKII alpha protein. Suitable for research use in neuronal signaling and calcium regulation studies. Supplied as liquid, stored at -2...
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Thermo Fisher Scientific CaMKII alpha Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:2,000 |
| ELISA | 1:5,000–1:10,000 |
| Immunoprecipitation (IP) | 5–10 µL/mg of lysate |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human CaMKII alpha / CAMK2A Protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
Target Information
CAMK2A (CaMKII alpha) is a serine/threonine kinase that regulates numerous cellular functions, including neuronal processes, gene expression, carbohydrate metabolism, cytoskeletal function, and calcium homeostasis.
Autophosphorylation of threonine 286 in the presence of Ca²⁺ and calmodulin activates CAMK2A, enabling a switch from calmodulin-dependent to calmodulin-independent activity.
CaMKII is ubiquitously expressed and plays key roles in cell cycle regulation, transcription, dendritic spine and synapse formation, neuronal plasticity, and calcium transport in skeletal muscle.
In neurons, it contributes structurally to actin cytoskeleton reorganization during plasticity by binding and bundling actin filaments in a kinase-independent manner.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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