Thermo Fisher Scientific Phospho-SHC (Ser36) Polyclonal Antibody
SHC 단백질의 Ser36 인산화 부위를 인식하는 Rabbit Polyclonal Antibody. Western blot, IHC, ICC, ELISA 등 다양한 응용에 적합. 고순도 Protein A 정제 및 안정적 액상 형태로 제공. 인체, 마우스, 랫트 반응성.
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Thermo Fisher Scientific Phospho-SHC (Ser36) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:200 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic phosphopeptide derived from human SHC around the phosphorylation site of Ser36 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Skp2 (S-phase Kinase-associated Protein 2) belongs to the family of F-box proteins that interact with the Cyclin A-Cdk2 complex. Skp2 is essential for the G1-S transition in both transformed cells and diploid fibroblasts. It is involved in the ubiquitination and degradation of p27. In normal tissues, Skp2 is expressed in tonsil and placenta, while in tumor tissues it is widely expressed, notably in lung, breast, ovarian, and endometrial cancers. Research indicates Skp2 plays a role in oncogenesis, especially in lymphomas and breast cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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