Thermo Fisher Scientific WASH2P Polyclonal Antibody

Applications

• Western Blot (WB): 1:1,000 dilution

Product Specifications

Product Specific Information

Predicted to react with bovine, mouse, and rat based on sequence homology.

Target Information

Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting.
Involved in endocytic trafficking of EGF and transferrin receptor recycling.
Regulates trafficking of endosomal α5β1 integrin to the plasma membrane, contributing to invasive cell migration.
In T-cells, involved in endosome-to-membrane recycling of receptors including TCR, CD28, and ITGAL; implicated in T-cell proliferation and effector function.
In dendritic cells, participates in endosome-to-membrane recycling of MHC class II, enabling antigen sampling, loading, and presentation during T-cell activation.
Involved in Arp2/3 complex-dependent actin assembly driving Salmonella typhimurium invasion independent of ruffling.
Participates in exocytosis of MMP14 leading to matrix remodeling during invasive migration, involving cooperation with the exocyst complex.
Negatively regulates autophagy independently from endosomal sorting by inhibiting BECN1 ubiquitination to inactivate PIK3C3/Vps34 activity.
[UniProt]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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