Thermo Fisher Scientific GABA(B) R1 (extracellular) Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Reconstitution: Add 25 µL, 50 µL, or 0.2 mL of double distilled water (DDW), depending on sample size.
The antibody ships as a lyophilized powder at room temperature. Upon arrival, store at -20°C.
Reconstituted solution can be stored at 4°C for up to 1 week. For longer storage, aliquot and keep at -20°C.
Avoid multiple freeze/thaw cycles. Centrifuge all antibody preparations before use (10,000 × g for 5 min).

Target Information

Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulate phospholipase A2, activate potassium channels, inactivate voltage-dependent calcium channels, and modulate inositol phospholipid hydrolysis.
Plays a critical role in fine-tuning inhibitory synaptic transmission.

• Presynaptic GABA-B-R: inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels
• Postsynaptic GABA-B-R: decrease neuronal excitability by activating inwardly rectifying potassium (Kir) conductance

Involved in synaptic inhibition, hippocampal long-term potentiation, slow-wave sleep, muscle relaxation, and antinociception.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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