Thermo Fisher Scientific FGF2 Polyclonal Antibody
FGF2 단백질을 인식하는 Thermo Fisher Scientific의 sheep 유래 polyclonal antibody. Western blot과 IHC에 사용 가능하며, 다양한 종에서 교차 반응. 동결 건조 형태로 제공되며, 장기 보관 시 -20°C에서 안정적 유지.
- 카탈로그번호
- OSB00003W
- 판매단위
- pk
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Thermo Fisher Scientific FGF2 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300–1:2,000 |
| Immunohistochemistry (IHC) | 1:300–1:2,000 |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Sheep / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptides from human basic FGF2 |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2104470 |
Product Specific Information
- Glycerol (1:1) may be added for additional stability.
- Reconstitute with 150 µL of distilled water.
- The peptides are homologous in many other species including rat and mouse.
Target Information
FGF2 (fibroblast growth factor basic, FGFb) belongs to the fibroblast growth factor (FGF) family and interacts with high-affinity transmembrane receptors to regulate cell proliferation and tissue neovascularization.
FGF2 exists as five isoforms with distinct intracellular localizations and functions:
- 18 kDa isoform: predominantly cytosolic, acts through cell surface receptors
- 22, 22.5, 24, and 34 kDa isoforms: nuclear, may signal independent of transmembrane receptor pathways
In humans, the FGF2 gene is located on chromosome 4q. It is involved in limb and nervous system development, wound healing, and tumor growth.
FGF2 mRNA contains multiple polyadenylation sites and is alternatively translated from non-AUG and AUG codons, producing five isoforms with distinct properties:
- CUG-initiated isoforms: nuclear, responsible for intracrine signaling
- AUG-initiated isoform: cytosolic, responsible for paracrine and autocrine signaling
Diseases associated with FGF2 dysfunction include Kaposi Sarcoma and corneal neovascularization.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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