Thermo Fisher Scientific FGF2 Polyclonal Antibody

Thermo Fisher Scientific FGF2 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Glycerol (1:1) may be added for additional stability.
• Reconstitute with 150 µL of distilled water.
• The peptides are homologous in many other species including rat and mouse.

Target Information

FGF2 (fibroblast growth factor basic, FGFb) belongs to the fibroblast growth factor (FGF) family and interacts with high-affinity transmembrane receptors to regulate cell proliferation and tissue neovascularization.
FGF2 exists as five isoforms with distinct intracellular localizations and functions:

• 18 kDa isoform: predominantly cytosolic, acts through cell surface receptors
• 22, 22.5, 24, and 34 kDa isoforms: nuclear, may signal independent of transmembrane receptor pathways

In humans, the FGF2 gene is located on chromosome 4q. It is involved in limb and nervous system development, wound healing, and tumor growth.
FGF2 mRNA contains multiple polyadenylation sites and is alternatively translated from non-AUG and AUG codons, producing five isoforms with distinct properties:

• CUG-initiated isoforms: nuclear, responsible for intracrine signaling
• AUG-initiated isoform: cytosolic, responsible for paracrine and autocrine signaling

Diseases associated with FGF2 dysfunction include Kaposi Sarcoma and corneal neovascularization.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.