Thermo Fisher Scientific TM2D1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000–1:3,000

Product Specifications

Product Specific Information

Predicted to react with Mouse and Rat samples.

Target Information

Proteolytic cleavage of the Amyloid protein precursor (APP) generates β-Amyloid and Amyloid A4 proteins, found in human platelets. Amyloid deposition is associated with type II diabetes, Down syndrome, and neurological disorders including Alzheimer’s disease. BBP (Beta-amyloid-binding protein), also known as TM2D1, is a 207 amino acid multi-pass membrane protein with a G protein-coupling module that interacts with the β-amyloid peptide of APP. In cell culture, BBP expression induces caspase-dependent vulnerability to β-amyloid peptide toxicity, suggesting a role in Alzheimer’s disease pathophysiology.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.