Thermo Fisher Scientific CD44 Monoclonal Antibody (OX-50), PE

Applications

• Flow Cytometry (Flow)
  Tested Dilution: Neat
  View 6 publications

Product Specifications

Additional Formats

• Unconjugated
• FITC
• Request custom conjugation

Product Specific Information

• Reconstitute with 1 mL of distilled water.
• After reconstitution, store product undiluted at 4°C in the dark.
• For FACS analysis, use 10 µL of the suggested working dilution to label 1×10⁶ cells in 100 µL.

Target Information

CD44 is a 100 kDa type 1 transmembrane glycoprotein widely expressed on human leukocytes, white matter of the brain, and some epithelial cells of the intestine and breast.
It acts as a receptor for hyaluronic acid (HA) and is involved in cell-cell interactions, adhesion, and migration.
CD44 participates in lymphocyte activation, recirculation, and homing, and may be upregulated in certain carcinomas related to metastatic potential.
It is expressed by hematopoietic and non-hematopoietic cells, epithelial tissues, and filopodia in cultured keratinocytes.
Alternative splicing generates multiple isoforms with distinct functions.
Diseases associated with CD44 dysfunction include superficial keratitis and lichen sclerosus.
CD44 may also be related to tumor metastasis formation.

For Research Use Only.
Not for use in diagnostic procedures or resale without express authorization.

제품 이미지