Thermo Fisher Scientific Alpha-Smooth Muscle Actin Polyclonal Antibody
Western blot, IHC, ICC/IF, ELISA 등 다양한 응용에 적합한 알파 평활근 액틴 폴리클로날 항체. 사람, 생쥐, 랫트 반응성. 친화 크로마토그래피 정제, 고농도 액상 제품. 세포골격 연구 및 평활근 표지용으로 이상적.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:1,000 | - |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 | 1 publication |
| ELISA | 1 µg/mL | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing amino acids 1–100 of human alpha-Smooth Muscle Actin (ACTA2) (NP_0016041) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.327 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804309 |
Product Specific Information
- Immunogen sequence:
MCEEEDSTAL VCDNGSGLCK AGFAGDDAPR AVFPSIVGRP RHQGVMVGMG QKDSYVGDEA QSKRGILTLK YPIEHGIITN WDDMEKIWHH SFYNELRVAP EEHPTLLTEA PLNPKANREK MTQI - Positive Samples: HeLa, SW480, A-549
- Cellular Location: Cytoplasm, cytoskeleton
Target Information
Smooth Muscle Actin belongs to the actin family of proteins, which are highly conserved and play essential roles in cell motility, structure, and integrity.
Alpha, beta, and gamma actin isoforms have been identified:
- Alpha actin: Major component of the contractile apparatus
- Beta and gamma actins: Involved in regulation of cell motility
Smooth muscle actin is an alpha actin found in skeletal muscle and smooth muscle vessel walls, gut wall, myometrium, and myoepithelial cells of breast and salivary glands.
It is involved in filament formation, muscle contraction, and cytokinesis.
Defects in the smooth muscle actin gene can cause familial thoracic aortic aneurysm type 6.
Actin isoforms differ slightly in their N-terminus, with sequences conserved in higher vertebrates.
Alpha-smooth muscle actin is abundant in vascular and visceral smooth muscle cells and also appears in fibroblastic stress fibers during wound healing and fibrocontractive diseases.
Multiple alternatively spliced variants have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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