Thermo Fisher Scientific TAL-1 Monoclonal Antibody (2TL242), eBioscience
인간 TAL-1 단백질을 인식하는 단클론 항체로, Western blot, IHC, ICC 등 다양한 분석에 적합합니다. TAL-1 관련 T-세포 백혈병 연구에 활용되며, 높은 순도(>90%)와 안정적인 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific TAL-1 Monoclonal Antibody (2TL242), eBioscience
Thermo Fisher Scientific TAL-1 Monoclonal Antibody (2TL242), eBioscience
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 5 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 20 µg/mL |
| Immunocytochemistry (ICC/IF) | Assay-Dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2TL242 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2572922 |
| Purity | >90% (SDS-PAGE) |
| Aggregation | <10% (HPLC) |
| Filtration | 0.2 µm post-manufacturing filtered |
Product Specific Information
The monoclonal antibody 2TL242 recognizes human TAL-1. The TAL-1 protein is encoded by the tal-1 (T-acute leukemia or stem cell leukemia (SCL)) gene and functions as a 42 kDa basic helix-loop-helix transcription factor involved in mediating cell growth and differentiation.
Rearrangements of the tal-1 gene are common in human T-cell acute leukemias (T-ALLs) and result in aberrant transcription in leukemic cells. TAL-1 expression in leukemic cells is localized to the nucleus, although both nuclear and cytoplasmic expression has been observed in normal cells such as erythroid precursors, megakaryocytes, endothelial cells, and macrophages within tissues like tonsil, cerebellum, kidney, lung, and spleen.
TAL-1 regulates embryonic and adult hematopoiesis and has been found to influence proliferation and differentiation of common myeloid precursors to monocytes and macrophages.
Applications Reported:
This 2TL242 antibody has been reported for use in western blotting, microscopy, immunohistochemical staining, and immunocytochemistry.
Applications Tested:
- Tested by immunohistochemistry of formalin-fixed paraffin-embedded human tissue using low or high pH antigen retrieval at ≤20 µg/mL.
- Tested by western blot of reduced Jurkat cell lysate at ≤5 µg/mL.
It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.
Target Information
TAL-1 is a basic helix-loop-helix transcription factor that regulates differentiation and survival during hematopoiesis. It is implicated in the genesis of hematopoietic malignancies and plays a role in erythroid differentiation. Mutations are associated with T-cell leukemia and melanoma. TAL-1 binds to the LIM domain-containing protein Rhombotin-2.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.