Thermo Fisher Scientific LDLR Monoclonal Antibody (5E6)
LDLR 단백질을 인식하는 Mouse monoclonal antibody로 인간 시료에 반응합니다. Western blot 및 ELISA에 사용 가능하며, 액상 형태로 제공됩니다. -20°C 보관하며 동결/해동 반복을 피해야 합니다. 연구용으로만 사용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
ELISA
- Tested Dilution: 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 5E6 |
| Immunogen | LDLR (NP_000518, 105–205 a.a) partial recombinant protein with GST tag. MW of GST tag alone is 26 kDa. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Storage Buffer | Ascites |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
PPKTCSQDEF RCHDGKCISR QFVCDSDRDC LDGSDEASCP VLTCGPASFQ CNSSTCIPQL WACDNDPDCE DGSDEWPQRC RGLYVFQGDS SPCSAFEFHC L
Target Information
The low density lipoprotein receptor (LDL-R) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands.
Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell, ending up in lysosomes where the protein is degraded and cholesterol becomes available for repression of HMG CoA reductase, the rate-limiting step in cholesterol synthesis.
Mutations in the LDL-R gene cause familial hypercholesterolemia.
LDL-R is also reported to be an entry factor for Hepatitis C virus, along with SCARB1, CLDN1, and CD81.
At least three isoforms of LDL-R are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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