Thermo Fisher Scientific LGI4 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Immunogen sequence:
SMFRLLQQLP SRGAHVFQPL LIARDQLAIL GSDFAFSQVL RLEPDKGLLE PLQELGPPAL VAPRAFAHIT MAGRRFLFAA CFKGPTQIYQ HHEIDLSA

Highest antigen sequence identity to the following orthologs:

• Mouse: 91%
• Rat: 90%

Target Information

The leucine-rich, glioma inactivated gene 4 (LGI4) is a member of the LGI family, in which LGI1 is the exemplar. The LGI family consists of four highly related proteins containing leucine-rich repeats (LRRs), similar to other transmembrane signaling molecules and receptors. LGI1 has been identified as a candidate tumor suppressor gene for glioma and plays a role in autodominant lateral temporal epilepsy (ADTLE), characterized by focal seizures with auditory symptoms.

Despite high homology with LGI1 and similar expression patterns, mutations in LGI4 have not been associated with ADTLE. However, the LGI4 gene is located in a region linked to benign familial infantile convulsions. A GC-to-AT polymorphism has been correlated with childhood absence epilepsy, and reduced LGI4 expression in cultured cells inhibits myelination, suggesting a role in neural development.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.