Thermo Fisher Scientific CD282 (Toll-Like Receptor 2) Recombinant Rabbit Monoclonal Antibody (TLR2/3894R)

Applications

• ELISA (assay-dependent)

Product Specifications

Product Specific Information

• Predicted to react with monkey and dog.

Target Information

TLR2 (Toll-Like Receptor 2) is a member of the Toll-like receptor family that plays a crucial role in pathogen recognition and activation of innate immunity. TLR proteins signal through adaptor molecules such as MyD88 and TIRAP to activate kinases and transcription factors including PKC alpha/beta and NF-kappa-B.
TLR2 forms heterodimers with TLR1 or TLR6 to recognize bacterial and mycoplasma lipoproteins. It is highly conserved across species and exhibits distinct expression patterns.
TLR2 is most abundantly expressed in peripheral blood leukocytes and mediates host responses to Gram-positive bacteria and yeast via NF-kappaB activation. It recognizes pathogen-associated molecular patterns (PAMPs) and induces cytokine production for effective immunity.
Human TLR2 is expressed in tonsils, microglia, lymph nodes, appendices, and activated B-cells. CD14+ monocytes express the highest levels of TLR2, followed by granulocytes, B-cells, and T-cells.
Expression is modulated by immune response modifiers: LPS, GM-CSF, IL-1, and IL-10 upregulate TLR2, whereas IL-4, IFN-γ, and TNF downregulate it in monocytes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.