Thermo Fisher Scientific Calretinin Monoclonal Antibody (DC8)

Applications

Tested Dilution

Publications

Immunohistochemistry (IHC)

-

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

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Product Specifications

Published species

Not Applicable

Host/Isotype

Rabbit

Class

Polyclonal

Type

Antibody

Clone

DC8

Immunogen

Recombinant human calretinin

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Storage conditions

2-8°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2925238

Product Specific Information

Calretinin, a calcium-binding protein with a molecular weight of 29 kD, is a member of the large family of EF-hand proteins that also includes S-100 protein. This antibody is useful for differentiating mesotheliomas from adenocarcinomas. Positive tissue: Human normal pleura lining/ malignant mesothelioma.

Expected Staining Pattern: Cytoplasmic and nuclear

Target Information

Calretinin is encoded by the CALB2 gene located on chromosome 16. It is a troponin C superfamily protein having six EF-hand structural motifs. The EF motif allows the protein to bind calcium, and function in calcium signaling, calcium buffering, and modulating neuronal excitability. Calretinin is expressed in the mesothelium, mast cells, some neural cells, hair follicles, and fat cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.