Thermo Fisher Scientific PAAF1 Polyclonal Antibody
Thermo Fisher Scientific의 PAAF1 Polyclonal Antibody는 인간 PAAF1 단백질을 인식하는 토끼 IgG 항체입니다. Western blot 및 IHC(파라핀 절편)에서 검증되었으며, 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human PAAF1. Recombinant protein control fragment (Product # RP-97489) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2645154 |
Product Specific Information
Immunogen sequence:
GNIYQLDVRS PRAPVQVIHR SGAPVLSLLS VRDGFIASQG DGSCFIVQQD LDYVTELTGA DCDPVYKVAT WEKQIYTCCR DGLVRRYQLS DL
Highest antigen sequence identity to the following orthologs:
- Mouse: 20%
- Rat: 22%
Target Information
PAAF1 inhibits proteasome 26S assembly and proteolytic activity by impairing the association of the 19S regulatory complex with the 20S core.
In case of HIV-1 infection, it is recruited by viral Tat to the HIV-1 promoter, where it promotes recruitment of the 19S regulatory complex through dissociation of the proteasome 26S. This process presumably enhances provirus transcription efficiency.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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