Thermo Fisher Scientific Melanophilin Monoclonal Antibody (OTI6E8)
Melanophilin 단백질을 인식하는 Thermo Fisher Scientific의 단클론 항체. Western blot 및 IHC(Paraffin)에서 검증됨. Human 시료 반응성, Mouse IgG2a 아이소타입. Affinity Chromatography로 정제된 액상 항체로, -20°C 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI6E8 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 295–600 of MLPH produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2724676 |
Target Information
Slac2-a (synaptotagmin-like protein homolog lacking C2 domains-a) links Rab27A on melanosomes with Myosin VA in melanocytes.
Slac2-a binds Myosin VA through a C-terminal region and GTP-bound Rab27A through its synaptotagmin-like protein homology domain (SHD), located near the N-terminus.
The transport of pigment and cytotoxic granules in melanocytes requires the stable formation of this complex. Mutations in the binding domains of the three protein components may cause albinism and/or severe immune disorders.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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