Thermo Fisher Scientific CENPO Polyclonal Antibody
Thermo Fisher Scientific의 CENPO Polyclonal Antibody는 인간, 마우스, 랫트 시료에 반응하는 Rabbit IgG 기반 항체입니다. Western blot 및 IHC(Paraffin) 분석에 적합하며, 단백질 A로 정제된 고순도 제품입니다. 세포분열 시 키네토코어 기능 연구에 활용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human CENPO |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Accurate chromosome segregation during mitosis requires a kinetochore to assemble correctly at the centromere of each chromatid and form a dynamic interface with the microtubules of the mitotic spindle.
The kinetochore assembly includes the multisubunit CENP-H/I complex, which can be divided into three functional classes based on phenotype analysis. One of these classes is referred to as the CENP-O class of proteins, of which CENPO is the exemplar.
These proteins form a stable complex with each other and are required for proper kinetochore function and for recovery from mitotic spindle damage.
CENPO has also been shown to be an autoantigen in a small population of anti-centromere antibody (ACA)-positive patients with scleroderma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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