Thermo Fisher Scientific CSK Polyclonal Antibody
CSK 단백질을 인식하는 Rabbit Polyclonal Antibody로, Human, Mouse, Rat 시료에 반응합니다. WB, IHC, ICC, Flow, ELISA 등 다양한 응용에 사용 가능하며, Protein A로 정제된 고순도 항체입니다. 세포 성장 및 신호 조절 연구에 적합합니다.
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- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| Flow Cytometry (Flow) | 1:20–1:100 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human CSK, amino acids 301–400 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CSK (C-terminal Src kinase) is a tyrosine kinase that downregulates SRC oncoprotein activity by phosphorylating its carboxy terminus. Disruption of this phosphorylation can lead to cell transformation, suggesting CSK may function as an antioncogene.
CSK is involved in regulating cell growth, differentiation, migration, and immune responses. It phosphorylates tyrosine residues in the C-terminal tails of Src-family kinases such as LCK, SRC, HCK, FYN, LYN, CSK, and YES1.
CSK is ubiquitously expressed as a ~50 kDa cytosolic protein, with a fraction localized to lipid rafts via interaction with PAG (Csk-binding protein).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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