Thermo Fisher Scientific SAP (SLAM-Associated Protein) Polyclonal Antibody
SAP(SLAM-Associated Protein)에 특이적인 Rabbit Polyclonal Antibody로, Human 및 Mouse 시료에서 반응합니다. Western blot, ICC/IF, ELISA 등에 사용 가능하며, 고순도 Affinity Chromatography로 정제되었습니다. PBS/glycerol buffer에 보관하며 -20°C에서 안정적입니다.
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Thermo Fisher Scientific SAP (SLAM-Associated Protein) Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1–128 of human SH2D1A (NP_002342.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.71 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804674 |
Product Specific Information
- Immunogen sequence: MDAVAVYHGK ISRETGEKLL LATGLDGSYL LRDSESVPGV YCLCVLYHGY IYTYRVSQTE TGSWSAETAP GVHKRYFRKI KNLISAFQKP DQGIVIPLQY PVEKKSSARS TQGTTGIRED PDVCLKAP
- Positive Samples: Jurkat, PC-3, Mouse spleen
- Cellular Location: Cytoplasm
Target Information
This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. It contains an SH2 domain and a short tail, and associates with the signaling lymphocyte-activation molecule (SLAM), acting as an inhibitor by blocking SHP-2 recruitment. It also binds to other surface molecules on activated T, B, and NK cells, modulating their signal transduction pathways. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 (Duncan disease), a rare immunodeficiency associated with Epstein-Barr virus susceptibility. Multiple transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일: PA5-88130_SAP_SH2D1A_O60880-1_Rabbit.svg, PA5-88130_SAP_SH2D1A_O60880-1_Rabbit_PDP.jpeg)
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