Thermo Fisher Scientific WHIP Polyclonal Antibody

Applications

• Western Blot (WB): Tested dilution 1:500–1:3,000

Product Specifications

Product Specific Information

• Recommended positive controls: 293T, A431, Jurkat, Raji
• Predicted reactivity: Mouse (97%), Rat (97%), Zebrafish (80%), Xenopus laevis (82%), Bovine (90%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Werner’s syndrome is a rare autosomal recessive disorder characterized by accelerated aging, caused by defects in the Werner syndrome ATP-dependent helicase gene (WRN).
The protein encoded by this gene interacts with the exonuclease-containing N-terminal portion of the Werner protein. It has a ubiquitin-binding zinc-finger domain in the N-terminus, an ATPase domain, and two leucine zipper motifs in the C-terminus.
This protein shows sequence similarity to replication factor C family proteins and is conserved from E. coli to human. It likely accumulates at sites of DNA damage by interacting with polyubiquitinated proteins and binds to DNA polymerase delta to increase the initiation frequency of DNA synthesis.
Additionally, it interacts with nucleoporins at nuclear pore complexes. Two transcript variants encoding different isoforms have been identified for this gene.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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