Thermo Fisher Scientific CD138 Monoclonal Antibody (1D4), PE-Cyanine5.5

Applications

• Flow Cytometry (Flow): Assay-Dependent

Product Specifications

Product Specific Information

The R-phycoerythrin (PE)-Cy5.5 tandem conjugate permits simultaneous multicolor labeling and detection of multiple targets with excitation by a single excitation source—the 488 nm line of the argon-ion laser.

Target Information

CD138 (syndecan 1) is a transmembrane proteoglycan that can bind a variety of cytokines and modulate their activity, as well as the activity of extracellular matrix components and influence many developmental processes.
CD138 is expressed mainly in differentiating keratinocytes and is transiently upregulated in all layers of the epidermis upon tissue injury. It is also highly expressed on plasma cells and can be detected even on fibroblasts, vascular smooth muscle cells, and endothelial cells.
Up-regulation and down-regulation of CD138 on the cell surface often correlate with the gain of cancerous characteristics. Serum levels of the shed soluble sCD138 are used as a prognostic factor of cancerogenesis.

Analyte Specific Reagent

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