Thermo Fisher Scientific TSC1 Monoclonal Antibody (OTI3A2), TrueMAB
TSC1 단백질을 인식하는 Mouse IgG2a 단클론 항체로, Western blot 및 IHC(Paraffin)에서 검증됨. 인간 시료 반응성. 고순도 친화 크로마토그래피 정제. PBS/BSA/glycerol buffer에 보존, 연구용으로 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3A2 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 836–1164 of human TSC1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Tuberous sclerosis complex (TSC) is an autosomal dominant tumor syndrome caused by mutations in either the TSC1 or TSC2 tumor suppressor genes. The products of these genes form a protein complex that indirectly decreases the signaling of mammalian Target of Rapamycin (TOR), a serine/threonine kinase regulating cell growth and cycle through nutrient and growth factor signals.
TOR activity is stimulated by Rheb, a Ras superfamily G-protein, when the GTP/GDP ratio bound to Rheb is high. Immunoprecipitated TSC1/TSC2 complex stimulates Rheb GTPase activity in vitro, reducing Rheb’s ability to activate TOR. Overexpression of TSC1 and TSC2 decreases the GTP/GDP ratio bound to Rheb and inhibits cell growth. A shorter 40 kDa isoform of TSC1 also exists, though its function remains unknown.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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