Thermo Fisher Scientific Filaggrin 2 Polyclonal Antibody
Human Filaggrin 2 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC(P)에서 1:200~1:500 희석 비율로 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS(glycerol 포함)에 보관. 피부 장벽 연구 및 FLG2 발현 분석에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human Filaggrin 2 (Recombinant protein control fragment: Product #RP-94294) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.08 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS (pH 7.2) with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2641637 |
Product Specific Information
Immunogen sequence:
CGYSNSSGCG RPQNASSSCQ SHRFGGQGNQ FSYIQSGCQS GIKGGQGHGC VSGGQPSGCG QPESNPCSQS YSQRGYGARE NGQPQNCGGQ WRTGSSQSSC CG
Sequence identity to orthologs:
- Mouse: 68%
- Rat: 35%
Target Information
The FLG2 protein is upregulated by calcium and proteolyzed by calpain 1. It plays a critical role in epithelial homeostasis and is essential for proper skin cornification. Mutations or defects in this gene are associated with skin diseases. Additionally, FLG2 contributes to skin barrier protection, with its C-terminal fragments exhibiting antimicrobial activity against Pseudomonas aeruginosa.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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