Thermo Fisher Scientific Filaggrin 2 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:500

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human Filaggrin 2. Recombinant protein control fragment (Product #RP-94294). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Filaggrin 2,uniProtId:Q5D862-1,ncbiNodeId:9606,antigenRange:280-381,antigenLength:2391,antigenImageFileName:PA5-55951_Filaggrin_2_Q5D862-1_Rabbit.svg,antigenImageFileNamePDP:PA5-55951_Filaggrin_2_Q5D862-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.08 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2641637

Product Specific Information

Immunogen sequence: CGYSNSSGCG RPQNASSSCQ SHRFGGQGNQ FSYIQSGCQS GIKGGQGHGC VSGGQPSGCG QPESNPCSQS YSQRGYGARE NGQPQNCGGQ WRTGSSQSSC CG

Highest antigen sequence identity to the following orthologs: Mouse - 68%, Rat - 35%.

Target Information

The FLG2 protein is upregulated by calcium, proteolyzed by calpain 1, and is involved in epithelial homeostasis. FLG2 is also required for proper cornification in skin, with defects in this gene being associated with skin diseases. This protein also has a function in skin barrier protection. In fact, in addition to providing a physical barrier, C-terminal fragments of this protein display antimicrobial activity against P. aeruginosa.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.