Thermo Fisher Scientific MMS19 Polyclonal Antibody
Human MMS19 단백질을 인식하는 Rabbit Polyclonal 항체로, ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS와 글리세롤 기반 완충액에 보관. 핵산 대사 관련 단백질 복합체 연구에 적합. 연구용으로만 사용.
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human MMS19. Recombinant protein control fragment (Product # RP-106363) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2791245 |
Product Specific Information
Immunogen sequence:
LVFMALTDPS TQLQLVGIRT LTVLGAQPDL LSYEDLELAV GHLYRLSFLK EDSQSCRVAA LEASGTLAAL YPVAFSSHLV PKLA
Target Information
MMS19 is a key component of the cytosolic iron-sulfur protein assembly (CIA) complex, which mediates the incorporation of iron-sulfur clusters into apoproteins involved in DNA metabolism and genomic integrity.
In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and target iron-sulfur proteins such as ERCC2/XPD, FANCJ, and RTEL1, playing a crucial role in nucleotide excision repair (NER) and RNA polymerase II transcription.
As part of the mitotic spindle-associated MMXD complex, MMS19 contributes to chromosome segregation by facilitating iron-sulfur cluster assembly into ERCC2/XPD.
It also indirectly acts as a transcriptional coactivator of estrogen receptor (ER) via its role in iron-sulfur insertion into components of the TFIIH machinery.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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