Thermo Fisher Scientific PABPC4 Polyclonal Antibody

Thermo Fisher Scientific PABPC4 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Immunogen sequence:
RPQGFQGMPS AIRQSGPRPT LRHLAPTGSE CPDRLAMDFG GAGAAQQGLT DSCQSGGVPT AVQNLAPRAA VAAAAP

Highest antigen sequence identity to the following orthologs:

• Mouse: 96%
• Rat: 95%

Target Information

Poly(A)-binding proteins (PABPs) bind to the poly(A) tail present at the 3-prime ends of most eukaryotic mRNAs.
PABPC4, also known as IPABP (inducible PABP), is an activation-induced T-cell mRNA encoding a protein. Activation of T cells increases PABPC4 mRNA levels approximately 5-fold.
PABPC4 contains 4 RNA-binding domains and a proline-rich C terminus, and is primarily localized to the cytoplasm. It is suggested to regulate the stability of labile mRNA species in activated T cells.
Additionally, PABPC4 was identified as APP1 (activated-platelet protein-1), expressed on thrombin-activated rabbit platelets. It may also be involved in protein translation regulation in platelets and megakaryocytes or in polyadenylate binding/stabilization in platelet dense granules.
Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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