Thermo Fisher Scientific PABPC4 Polyclonal Antibody
Human PABPC4 단백질에 특이적인 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 재현성 제공. 세포 내 mRNA 안정성 및 번역 조절 연구에 적합.
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Thermo Fisher Scientific PABPC4 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human PABPC4. Recombinant protein control fragment (Product #RP-94047). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.8 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2645156 |
Product Specific Information
Immunogen sequence:
RPQGFQGMPS AIRQSGPRPT LRHLAPTGSE CPDRLAMDFG GAGAAQQGLT DSCQSGGVPT AVQNLAPRAA VAAAAP
Highest antigen sequence identity to the following orthologs:
- Mouse: 96%
- Rat: 95%
Target Information
Poly(A)-binding proteins (PABPs) bind to the poly(A) tail present at the 3-prime ends of most eukaryotic mRNAs.
PABPC4, also known as IPABP (inducible PABP), is an activation-induced T-cell mRNA encoding a protein. Activation of T cells increases PABPC4 mRNA levels approximately 5-fold.
PABPC4 contains 4 RNA-binding domains and a proline-rich C terminus, and is primarily localized to the cytoplasm. It is suggested to regulate the stability of labile mRNA species in activated T cells.
Additionally, PABPC4 was identified as APP1 (activated-platelet protein-1), expressed on thrombin-activated rabbit platelets. It may also be involved in protein translation regulation in platelets and megakaryocytes or in polyadenylate binding/stabilization in platelet dense granules.
Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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