Thermo Fisher Scientific ITGB5 Polyclonal Antibody
Integrin beta 5 단백질을 검출하는 Thermo Fisher Scientific의 폴리클로날 항체. Western blot, IHC, ICC/IF 등 다양한 응용 가능. 인간, 생쥐, 랫트 반응성. 고순도 친화 크로마토그래피 정제. 연구용 전용 제품.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human ITGB5 (Accession P18084), corresponding to amino acid residues A726–K776 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2903001 |
Product Specific Information
Antibody detects endogenous levels of total Integrin beta 5.
Target Information
Integrins are important extracellular matrix (ECM) receptor proteins located on cell surfaces. They are heterodimers composed of an alpha and a beta transmembrane glycoprotein subunit. Around 22 different integrins (different alpha/beta subunit combinations) are found in nature. Integrins are generally present in high concentrations at the cell surface, but unlike most other cell-surface receptors, they bind ligands with very low affinity. Due to their weak individual binding, integrins need to cluster and bind in groups to effectively bind the ECM. Integrins bind many different ligands including laminin. Each integrin is made up of a large N-terminal extracellular domain that binds the ECM ligand and a small C-terminal cytoplasmic domain that mediates interaction with the actin cytoskeleton and signaling function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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