Thermo Fisher Scientific HPK1 Polyclonal Antibody
HPK1 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF 등 다양한 응용에 적합합니다. Human MAP4K1(HPK1) 특이적 반응성을 가지며, 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용됩니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
| Immunocytochemistry (ICC/IF) | 5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to a region within amino acids 1–44 of Human MAP4K1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 40% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2545569 |
Product Specific Information
- Recommended positive control: HeLa cells
- Store product as a concentrated solution.
- Centrifuge briefly prior to opening the vial.
Target Information
MAP4K1 (also known as HPK1, Hematopoietic Progenitor Kinase 1) is a hematopoietic cell-restricted member of the Ste20 serine/threonine kinase superfamily. It acts as a tissue-specific upstream activator of the MEKK/JNK/SAPK signaling pathway.
HPK1 reduces T cell receptor (TCR) signaling and T cell proliferation by phosphorylating the adaptor protein SLP-76. JNKs/SAPKs play a crucial role in stress responses in mammalian cells.
HPK1 is expressed predominantly in hematopoietic cells, including early progenitor cells, and specifically activates JNK1, enhancing AP-1-mediated transcriptional activity. It binds and phosphorylates MEKK1 directly, but does not interact with Rac1 or Cdc42, distinguishing it from PAK65.
⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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