Thermo Fisher Scientific ACE2 Monoclonal Antibody (OTI1G4), TrueMAB

Thermo Fisher Scientific ACE2 Monoclonal Antibody (OTI1G4), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

Angiotensin-converting enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology. Unlike its homolog ACE, ACE2 expression is limited to the heart, kidney, and testis. ACE2 also functions as a receptor for SARS coronavirus.
ACE2 converts the inactive vasoconstrictor Angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, while ACE converts AngI to AngII.
Deficiency of ACE2 in knockout mice results in severely reduced cardiac contractility, highlighting its importance in heart function regulation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.