Thermo Fisher Scientific ACE2 Monoclonal Antibody (OTI1G4), TrueMAB
인간 ACE2 단백질을 표적으로 하는 단클론 항체로, Western blot 및 IHC(P) 실험에 최적화됨. 마우스 IgG1 아이소타입, 무보존제, 동결건조 형태. 심혈관 및 바이러스 연구용으로 적합하며, 재구성 및 결합 실험에 용이함.
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Thermo Fisher Scientific ACE2 Monoclonal Antibody (OTI1G4), TrueMAB
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1G4 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 18–237 of human ACE2 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
Angiotensin-converting enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology. Unlike its homolog ACE, ACE2 expression is limited to the heart, kidney, and testis. ACE2 also functions as a receptor for SARS coronavirus.
ACE2 converts the inactive vasoconstrictor Angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, while ACE converts AngI to AngII.
Deficiency of ACE2 in knockout mice results in severely reduced cardiac contractility, highlighting its importance in heart function regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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