Thermo Fisher Scientific TDP-43 Polyclonal Antibody
TDP-43 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, ICC/IF, ELISA에 사용 가능. 인간, 마우스, 랫트 반응성. 고순도 친화성 정제 제품으로 핵 내 TDP-43 검출에 적합. 연구용으로만 사용.
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Thermo Fisher Scientific TDP-43 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing amino acids 1–100 of human TDP-43/TARDB (NP_0314011) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.73 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2805425 |
Product Specific Information
- Immunogen sequence: MSEYIRVTED ENDEPIEIPS EDDGTVLLST VTAQFPGACG LRYRNPVSQC MRGVRLVEGI LHAPDAGWGN LVYVVNYPKD NKRKMDETDA SSAVKVKRAV
- Positive Samples: SW620, HeLa, Jurkat, HepG2, Mouse spleen, Mouse brain, Mouse thymus
- Cellular Location: Nucleus
Target Information
TDP43 was first identified as a novel cellular protein that binds to the HIV-1 TAR DNA sequence and acts as a transcriptional repressor of the HIV-1 LTR. It also regulates the splicing of exon 9 of the CFTR gene through association with UG repeats at the 3' splice site. Pathologic TDP43, a hyperphosphorylated and ubiquitinated form, is the major disease protein in ubiquitin-positive, tau-, and alpha-synuclein-negative frontotemporal dementia (FLTD-U). TDP43 is distinct from TRBP1, another RNA-binding protein that interacts with HIV-1 TAR RNA sequences.
Usage Notice
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일: PA5-89219_TDP-43_Q13148-1_Rabbit.svg, PA5-89219_TDP-43_Q13148-1_Rabbit_PDP.jpeg)
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