Thermo Fisher Scientific PXR Polyclonal Antibody
PXR 단백질을 인식하는 Rabbit Polyclonal 항체로, 인간·마우스·랫트 시료에 반응합니다. Western blot 및 ELISA에 적합하며, 합성 펩타이드(aa 100–200)로부터 유래했습니다. 친화 크로마토그래피로 정제되었으며, PBS/glycerol buffer에 보존됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 100–200 of human PXR (NP_071285.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.62 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20 °C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2901272 |
Product Specific Information
- Positive Samples: Rat liver
- Immunogen sequence:
CKGFFRRAMK RNARLRCPFR KGACEITRKT RRQCQACRLR KCLESGMKKE MIMSDEAVEE RRALIKRKKS ERTGTQPLGV QGLTEEQRMM IRELMDAQMK T
Target Information
This gene product belongs to the nuclear receptor superfamily, whose members function as transcription factors with ligand-binding and DNA-binding domains. The encoded protein regulates the cytochrome P450 gene CYP3A4, binding to its promoter as a heterodimer with the 9-cis retinoic acid receptor (RXR). It is activated by compounds such as dexamethasone and rifampicin that induce CYP3A4 expression. Several alternatively spliced transcripts and isoforms have been described, some using non-AUG initiation codons. Additional transcript variants exist but are not fully characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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